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Very limited human data

Glutathione peroxidase 2 inhibits cyclooxygenase-2-mediated migration and invasion of HT-29 adenocarcinoma cells but supports their growth as tumors in nude mice

[5] [6] The effects of persistent high cortisol are wide-ranging and can include: Weight gain , particularly around the abdomen and face Insulin resistance and increased risk of type 2 diabetes Hypertension (high blood pressure) Osteoporosis and increased fracture risk Mood disturbances , including anxiety and depression Immune suppression , leading to increased infection susceptibility Muscle weakness and skin changes The relationship between cortisol and metabolic health is particularly significant