does semaglutide help with autoimmune and Diseases (Ozempic and Wegovy) Semaglutide and Autoimmune Disease: Safety

Key points: In the only head-to-head trial, Wegovy produced 15.8% weight loss compared with 6.4% for Saxenda over the same 68-week period Wegovy 7.2 mg (approved January 2026) produces even greater results at 20.7% average weight loss Real-world data from Second Nature shows 19.1% weight loss with semaglutide when combined with behavioural support Semaglutide participants were nearly three times more likely to achieve at least 10% weight loss than liraglutide participants Side effects and tolerability Both medications share a similar side-effect profile, predominantly affecting the gastrointestinal tract

Expert Interpretations Experts in diabetes and digestive health have examined these findings to provide actionable insights

Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: Systematic review and network meta-analysis

Oral semaglutide exposure-response relationships determine HbA 1c reduction The change in HbA 1c from baseline until week 26 with once-daily oral semaglutide was exposure dependent and started to level off at higher exposures (Figure S2A)