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An initial phase 2 trial (NCT00809562) indicated that basimglurant (an mGlu5-negative allosteric modulator) was well tolerated in people with TRD, but formal results were not published

These results demonstrate that the 127 gene signature is related to regional emphysema severity within individuals and not to differences between donors and COPD patients or to differences in levels of emphysema between COPD patients