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While some trials show no major changes in BMD, others suggest slight improvements in bone turnover markers: Trials of liraglutide and exenatide generally show stable BMD over 612 months Certain populations such as postmenopausal women or individuals with rapid weight loss may show changes in bone markers like osteocalcin and P1NP However, most of these studies are small, short-term, or not powered for skeletal endpoints

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Governor Maura Healey included that request in the supplemental budget she submitted earlier this month.

Reconstitute in sterile bacteriostatic water or sterile saline