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256 In contrast, the herpes simplex virus (HSV) preferentially infects astrocytes and oligodendrocytes, whereas microglia become reactive and neuroprotective through release of inflammatory mediators, such as interferon-, TNF-, IL-1, IL-6 and IL-8, RANTES and chemokine CXCL10

Mar 2011;121(3):617-21

Other common GI symptoms include: Diarrhea (approximately 30% of patients) Constipation (24%) Vomiting (24%) Abdominal discomfort or bloating Decreased appetite (which is therapeutic but can feel uncomfortable initially) These effects are generally mild to moderate and resolve within several weeks as your body adjusts

These medications also reduce appetite-driven eating disorders, lower blood sugar in type 2 diabetes, and decrease heart attack and stroke risk independent of weight loss