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This is a critical issue, as a decrease in muscle mass leads to a reduction in basal metabolic rate [41, 42], which could hinder the long-term benefits of obesity treatment by impairing the overall metabolic profile

The most common TEAEs were mild to moderate GI symptoms

(Note that on November 19, 2024, the parties filed a joint status report in the case where FDA indicated it has not yet made a determination in its reconsideration of the status of tirzepatide and will provide another update to the court on December 19, 2024

Obesity is associated with glutamatergic neurotransmission and synaptic plasticity mediated by NMDA receptors