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In addition, interactions between essential and toxic metals involve both competitive and protective mechanisms that influence metal uptake, transport, and detoxification

Microbiota-derived GABA may reach the brain via circulation or neural pathways, potentially modulating anxiety and sleep, though direct CNS penetration in humans remains to be conclusively demonstrated

Oleandrin induces immunogenic cell death via the PERK/elF2/ATF4/CHOP pathway in breast cancer

For example, the SELECT trial clearly demonstrated that semaglutide significantly reduces the risk of major adverse cardiovascular events (MACE), leading to FDA approval for lowering the risk of cardiovascular death, myocardial infarction, or stroke in overweight or obese adults with established cardiovascular disease (Marso et al., 2016a)