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We investigated Wnt/LRP5/-catenin as an upstream signaling pathway for the first time and further identified the key role of LRP5 in Wnt, which can be reflected in some of the current studies (Esen et al., 2013

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Incretin mimetics or enhancers are one of the latest groups of drugs available for the treatment of T2DMincretin therapy

Observed molecular effects are dependent on experimental design, concentration, and model system and are used to investigate IGF-1 receptor signalling rather than defined biological or physiological outcomes