Several important considerations apply: Individuals with active or severe gastrointestinal disease may experience worsening symptoms due to the gastrointestinal side effects of GLP-1 medications The slowed gastric emptying caused by these drugs could theoretically exacerbate symptoms in people with strictures or obstructive complications of Crohn's disease Weight loss associated with GLP-1 therapy may be inappropriate in patients with Crohn's disease who are already experiencing malnutrition or unintentional weight loss The interaction between GLP-1 medications and the inflammatory processes in IBD is not fully understood Clinical decision-making should involve a thorough assessment of disease activity, nutritional status, presence of complications (such as strictures or fistulas), and the primary indication for GLP-1 therapy

Feature comparison Mounjaro Also known as tirzepatide Starting from 34/week Expected weight loss 26% Frequency Once weekly Eligibility BMI over 30* Easy to administer Yes In stock Yes Free delivery Yes Learn moreNo Potential side effects Nausea Very common Diarrhoea Very common Vomiting Very common Constipation Very common Headache Common Upset stomach Common Feeling weak or tired Common Dizziness Common Reflux or heartburn Common Gas Common Injection site reaction Common Allergic reaction Common Gallstones Uncommon Hair loss Common Poor sleep No Increased calcitonin levels Uncommon Inflamed gallbladder (cholecystitis) Uncommon Delay in emptying stomach No Acute pancreatitis Uncommon Severe allergic reaction Rare Reduced kidney function No Wegovy Also known as semaglutide Starting from 20/week Expected weight loss 15% Frequency Once weekly Eligibility BMI over 30* Easy to administer Yes In stock Yes Free delivery Yes Learn moreNo Potential side effects Nausea Very common Diarrhoea Very common Vomiting Very common Constipation Very common Headache Very common Upset stomach Very common Feeling weak or tired Very common Dizziness Common Reflux or heartburn Common Gas Common Injection site reaction Common Allergic reaction Common Gallstones Common Hair loss Common Poor sleep No Increased calcitonin levels No Inflamed gallbladder (cholecystitis) No Delay in emptying stomach No Acute pancreatitis Uncommon Severe allergic reaction Rare Reduced kidney function No Saxenda Also known as liraglutide Starting from 55/pen Expected weight loss 10% Frequency Once daily Eligibility BMI over 30* Easy to administer Yes In stock Yes Free delivery Yes Learn moreNo Potential side effects Nausea Very common Diarrhoea Very common Vomiting Very common Constipation Very common Headache Very common Upset stomach Common Feeling weak or tired Common Dizziness Common Reflux or heartburn Common Gas Common Injection site reaction Common Allergic reaction Common Gallstones Common Hair loss No Poor sleep Common Increased calcitonin levels No Inflamed gallbladder (cholecystitis) Uncommon Delay in emptying stomach Uncommon Acute pancreatitis Rare Severe allergic reaction Rare Reduced kidney function Rare Feature comparison Potential side effects *BMI over 27 if you have a weight related condition such as dysglycaemia (prediabetes or type 2 diabetes mellitus), hypertension, dyslipidaemia, or obstructive sleep apnoea

The most common side effects are gastrointestinal: nausea (especially during dose increases), occasional vomiting, diarrhea, constipation, and abdominal discomfort
Its too soon to say whether the mices altered running habits actually relate to the more complicated exercise decisions that people make