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Left: Many cancer cells generate large amounts of ROS and RNS but also have elevated antioxidant defenses, largely through upregulation of the Trx and GSH systems

As a result of the reduction in oxidative stress and increase in H 2 S levels and mtNOS activity, we observed improved endothelium-dependent relaxation which dramatically deteriorated with aging ( Such positive changes in the redox status of the myocardium increase its resistance to ischemic effects

Sonication involves exposing samples to ultrasonic waves which agitate the molecules and increase the solubility of peptide compounds in solution