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Finally, mechanistic studies showed that the activation of nuclear factor-kappa B (NF-B) was involved in the SGNs damage caused by peroxynitrite and that GPX1 protected SGNs against peroxynitrite-induced damage, at least in part, via blocking the NF-B pathway activation

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VEGF also regulates and shapes immunosuppressive TME by inhibiting dendritic cell maturation, preventing antigen presentation, and by polarizing macrophages toward an M2 phenotype