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63 By recognizing these signals, inflammasomes play a crucial role in initiating and regulating the inflammatory response in the body, particularly in response to cellular damage or microbial threats

Other studies have demonstrated elevated activities of SOD1 and SOD2 within active demyelinating lesions ( 2 O 2 accumulation and exacerbate OS ( 1 HMRS) studies have further revealed reduced GSH levels in specific brain regions of MS patients ( Beyond classical antioxidant enzymes, dysregulation of multiple OS-related proteins and pathways has been reported in MS, including peroxiredoxin (PRX), an enzyme critical for reducing H 2 O 2 whose dysregulation may impair the cellular ability to handle peroxides ( 2.3 The inflammatory-oxidative axis in MS In MS pathogenesis, the inflammation-driven oxidative burst generated by activated microglia, astrocytes, and infiltrating macrophages play a critical role in demyelination and subsequent injury to neurons, axons, myelin, and oligodendrocytes (Figure 2)

Drug Test Anal 3, 652-60 (2011)

Circulation 118 , 19291937 (2008)