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Increasing healthcare awareness, growing disposable incomes, and expanding access to modern therapeutics are accelerating demand for advanced treatment options

GLP-1R may ameliorate these conditions by improving insulin signaling and reducing insulin resistance in the brain

However, as major countries begin incorporating GLP-1 therapies into public healthcare systems, obesity is increasingly being recognized as a treatable chronic disease rather than a consequence of lifestyle choices

It has been reported that GLP-1RAs can enhance bone mineral density (BMD), improve bone quality and prevent fractures in diabetic patients and cell and animal experiments further found that GLP-1RAs have excellent potential anti-osteoporosis benefits for postmenopausal osteoporosis, GIOP and senile osteoporosis (Zhang et al., 2018