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Quantification of phospho-Akt protein revealed that insulin-induced Akt phosphorylation was significantly less in Insr P1195L/ +/ND mice and in WT/HFD mice compared with that in WT/ND mice
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At maximum doses, retatrutide has higher rates of nausea (43% vs 31%), vomiting (21% vs 12%), diarrhea (33% vs 23%), and constipation (25% vs 11%) compared to tirzepatide
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