They repeat the same generic steps without explaining why each step matters or what happens when you skip one
From the limiting membrane of EEs, GPCRs may be recycled back to the plasma membrane via a short/fast cycle of trafficking from a Rab5-positive to a Rab4-positive endocytic compartment, via a long/slow cycle by entering Rab11-positive perinuclear recycling endosomes, or towards lysosomal degradation via retention in intraluminal vesicles (ILVs) of multivesicular bodies (MVBs), generated by maturation of EEs, a process that also causes termination of signalling, and subsequent trafficking to Rab7-positive late endosomes and lysosomes (90)
Currently, the PROTECT-ME study (ACTRN12617001515381), a triple-blind, randomized, parallel group, placebo-controlled trial, is trying to determine whether antenatal maternal melatonin supplementation improves neurodevelopmental outcomes at 2 years of age in children affected by FGR
doi: 10.1056/NEJMoa1901118 55 RosenstockJAllisonDBirkenfeldALBlicherTMDeenadayalanSJacobsenJBet al
