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24 , 25 Growth factors, such as transforming growth factor (TGF) and growth and differentiation factors (GDFs), positively affect ECM metabolism and thus loss of growth factors can further promote degenerative processes

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However, it is currently unclear whether individual organelles contribute to ferroptosis through impaired cell signalling, metabolism and biosynthesis of specific biomolecules or whether membrane lipids of these compartments are also direct substrates for iron-mediated oxidation that leads to cell death

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