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Diabetes 58 , 16341640 (2009)

For example, one study found no significant differences in bacterial DNA sequencing results obtained from the caecal contents of 4-week-old and 10-13-week-old mice

While analogs with reduced IGFBP affinity show increased potency in vitro, careful pharmacokinetic work has shown that such analogs are actually cleared more rapidly than native IGF-1 after parenteral administration in vivo, because the binding proteins that inhibit activity also serve as a circulating reservoir that prolongs systemic presence

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