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Sitagliptin downregulated Keap-1 expression in diabetic kidney to activate the antioxidant response through the Nrf2 signaling pathway and improved renal morphology and clinical manifestations ( DPP-4i plays an anti-apoptotic role by regulating the mitogen-activated protein kinase (MAPK)/ERK, phosphatidylinositol-3-kinase (PI3K)/AKT and NF-B signaling pathways