Together, they represent the kind of systems-based prevention that has a much stronger foundation than any single brain hack. The bottom line GLP-1 medications are interesting in the brain-health conversation because metabolism, vascular health, inflammation, and cognitive aging are connected
CrossRef Original Articles Basic and Translational Research Serpina3c Mitigates Adipose Tissue Inflammation by Inhibiting the HIF1-Mediated Endoplasmic Reticulum Overoxidation in Adipocytes Yu Jiang, Jia-Qi Guo, Ya Wu, Peng Zheng, Shao-Fan Wang, Meng-Chen Yang, Gen-Shan Ma, Yu-Yu Yao Diabetes Metab J
Following cholecystectomy in patients with history of MBS, postprandial levels of insulin and C4 (a marker of hepatic BA synthesis) are two to three times higher than those of patients with history of MBS who did not undergo cholecystectomy [11]
This effect is significant given the studies in humans where acute insulin treatment inhibits intestinal lipoprotein secretion in response to hourly meals, an effect partially lost upon concomitant Intralipid and heparin infusion (Pavlic et al., 2010), suggesting mediation by FFA