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However, more participants discontinued treatment with tirzepatide 10 mg (OR 2.39 [95% CI 1.02, 5.59], I 2 0%) and 15 mg (OR 3.64 [95% CI 1.51, 8.78], I 2 13%) when compared with placebo (ESM Table 3)

Skipping titration steps : Patients may mistakenly start at higher doses or escalate too quickly, increasing the risk of severe nausea, vomiting, and dehydration