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Here, we demonstrated that long-term oscillating glucose challenge in vivo resulted in desensitization of insulin secretion due to -cell mass exhaustion, which was caused by -cell dedifferentiation

NAD+ depletion can slow DNA repair, accelerate aging, and contribute to disease progression

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If intestinal permeability is indeed present in hypertension and involved in its pathophysiological mechanisms, another important question is if BP and its associated end-organ damage could be lowered by a reduction in intestinal permeability