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b , Top-down view of structural overlay of the active GLP-1R transmembrane domain and the inactive CRF 1 R transmembrane domain (PDB code: 4K5Y) indicates the conformational similarity of ECL2 in the two structures
Hence, the use of such drugs may have a multisystem effect and lead to the development of chronic illnesses such as ME/CFS
Note on humans: These benefits are not established in humans no completed clinical trials exist [1]
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