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2024, [7] J

11, 2025 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) today announced positive topline results from the Phase 3 TRIUMPH-4 clinical trial evaluating the safety and efficacy of the two highest investigational doses of retatrutide, a first-in-class GIP, GLP-1 and glucagon triple hormone receptor agonist, in adults with obesity or overweight and knee osteoarthritis, and without diabetes, as an adjunct to healthy diet and physical activity

The agitation from vigorous shaking creates mechanical forces that can break peptide bonds, so gentle handling of the vial at all times protects medication effectiveness

Determine which patients are suitable for tirzepatide therapy based on their clinical characteristics and desired course of treatment