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doi: 10.1038/nn.3554 143 HikosakaM.KawanoT.WadaY.MaedaT.SakuraiT.OhtsukiG.et al

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These were rats having permanent major vessel occlusion, peripherally [18,19,20,21,22] and centrally [24], or with other similar noxious procedures applied [26,27,28,29,30], which severely affect endothelium function

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