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Melanoma is more aggressive than nonmelanoma, meaning its more likely to spread to other parts of the body and can spread quickly

Seek emergency care if: you experience severe abdominal pain radiating to your back (possible pancreatitis), persistent vomiting that prevents hydration for more than 24 hours, signs of severe dehydration (fainting, confusion, dark concentrated urine), or if you suspect you administered five or more times your intended dose

One figure cuts against the trend

For participants in clinical trials, all adverse events including GI symptoms should be reported to the trial team as per the study protocol, regardless of perceived severity