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This is critical for maintaining a healthy immune system, as chronic oxidative stress can impair immune function and increase susceptibility to infections

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This finding is consistent with the speculation that p53 is widely regarded as undruggable. Surprisingly, several novel therapeutic approaches targeting p53, including MDM2/4 antagonists, compounds that target specific p53 mutants or restore the wild-type function of the mutated p53 protein, p53-based genetic therapies and p53-based tumor immunotherapy, have been developed in recent years

Details of equivalent of protected amino acid/fragment, reagent and solvent were as below: On completion of solid phase synthesis the resin was removed from the assembly and dried to get Boc- Tyr(tBu) 1 - Aib - Glu(OtBu) - Gly - Thr(tBu) 5 - Phe - Thr(tBu) - Ser(tBu) - Asp(OtBu) - Tyr(tBu) 10 - Ser(tBu)- He - Aib - Leu - Asp(OtBu) 15 - Lys(Boc) - lie - Ala - Gln(Trt) - Lys 20 (Side chain) - Ala - Phe - Vai - Gln(Trt) - Trp 25 - Leu - He - Ala - Gly - Gly 30 - Pro - Ser(tBu) - Ser(tBu) - Gly - Ala35 - Pro - Pro - Pro - Ser(tBu) 39 -Rink Resin -32g (Boc-(01-39)-Rink Resin)