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Tirzepatide demonstrated remarkable weight-reducing efficacy in randomized controlled trials such as SURMOUNT-1 and SURMOUNT-2, with mean body-weight reductions ranging from 15 to 22.5% ( 4.3 Modulation of inflammatory status by tirzepatide Beyond metabolic regulation, obesity-related OSAS is closely linked to chronic low-grade systemic inflammation driven by intermittent hypoxia

doi: 10.1016/j.cell.2025.05.043, 161 ZhangQ.DelessaC