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However, formulations should be carefully evaluated as combination products (particularly those with amino acids or cross-linked derivatives) may require stability testing under tropical humidity and heat conditions to prevent degradation

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S1), in which glutamate is added and liberated at discrete steps (4, 11)

The most studied targets in mCRPCPSMA, STEAP1, TROP2, CD46, and B7H3are not exclusive to nor uniformly or highly expressed across all tumor cells, impairing ADC binding and internalization, reducing effective payload delivery, and increasing the risk of on-target, off-tumor toxicity 5