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Intern Med 31:841846 Trinchese F, Fa M, Liu S, Zhang H, Hidalgo A, Schmidt SD et al (2008) Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

What NAPQI does: Directly binds to and damages cellular proteins Depletes glutathione rapidly Generates oxidative stress which damages DNA Triggers cell death Damages mitochondria, disrupting energy production NAPQI crosses the placenta and depletes fetal brain glutathione at doses below those causing maternal liver toxicity