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Epithelial mesenchymal transition (EMT) refers to the morphological transformation of epithelial cells into a fibroblastic or mesenchymal cell phenotype, with loss of cell polarity, cytoskeletal rearrangement, and increased migratory motility

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However, disruption of this equilibrium, for example through the blockage of mitochondrial fusion and fission, may lead to oxidative stress, mitochondrial dysfunction and metabolic alterations, and ultimately to the development of mitochondria-associated diseases (Archer, 2013

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