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4501-C AZATHIOPRINE ON RISK OF EXTRAHEPATIC MALIGNANCY IN PATIENTS WITH AUTOIMMUNE HEPATITIS: A NATIONWIDE CLAIMS STUDY IN SOUTH KOREA Sung Hwan Yoo, Jung Il Lee and Hyun Woong Lee, Gangnam Severance Hospital Background: Long-term immunosuppressive therapy in patients with autoimmune hepatitis (AIH) increases the risk of extrahepatic malignancy in addition to hepatocellular carcinoma

This suggests that glutathione overproduction may be indispensable for the survival and proliferation of primary tumor cells, making the inhibition of glutathione production a promising therapeutic avenue for lymphoid tumors

Perni M, Mannini B