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To correct for this, we performed RNA-seq analysis of hypothalami obtained from animals treated with daily injections of either GLP-1MK-801 or a dose of semaglutide that was equipotent in terms of weight-lowering efficacy over 5 days of treatment, that is, mice had achieved a comparable weight loss and reduction in food intake as that of GLP-1MK-801-treated mice (Extended Data Fig

doi: 10.1111/anae.14180

Efficacy and safety of mazdutide in Chinese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 2 trial