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[27] Vitamin B 12 deficiency has the potential to influence methylation patterns in DNA, besides other epigenetic modulators such as micro (RNAs), leading to the altered expression of genes

3.1.1 The role of Se in GD A large number of studies have now confirmed Se deficiency as a risk factor for GD in areas with adequate soil Se levels ( Based on the damage to thyroid cells caused by low Se level, researchers have raised the possibility that Se supplementation may be beneficial in GD and have conducted a series of clinical studies ( Although the current findings are ambiguous and evidence from clinical trials does not favor the use of Se as a routine treatment option in GD, nor does the use of Se supplementation affect the remission and recurrence rates of GD ( 3.1.2 The role of Se in GO Current studies suggest that fibroblasts are distributed in the posterior globular connective tissue and ocular myofilament

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10.1186/s12906-017-1763-7 4 AlfawazH.Al-OnaziM.BukhariS