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The EMA classifies it as safe, and adverse effects reported in clinical trials are generally mild and transient

It is a term which has often been used to mystify rather than clarify...it is frequently used as a device to cast an aura of legitimacy over the final resolution of policy questions where there are still significant areas of disagreement. (Campbell and Marshall, 2000, p.308) The concept is simultaneously a carrier of many meanings and of no meaning

Additionally, G-quadruplexes tend to accumulate 8oxoG lesions, which are affected by the base excision repair pathway

Interestingly, it has been reported that SFN inhibited the activation of NLRP1, NLRP3, and NLRC4 inflammasomes [66,67]