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However, the relationship between receptor function and static structures determined via crystallography or cryo-electron microscopy is not always clear

Finally, long-term safety follow-up (12 months) is essential to assess risks of chronic Nrf2 activation (e.g., cancer progression) or antioxidant interference with physiological ROS signaling, highlighted by the bardoxolone methyl experience in diabetic kidney disease (Nangaku et al., 2020)

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The process typically involves a consultation with a healthcare provider and blood tests to confirm a deficiency