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The study conducted on a mouse model of non-small cell lung cancer found that while anamorelin effectively increased growth hormone levels and showed a trend toward higher IGF-1, it did not promote tumor growth: Anamorelin (ONO-7643) is an orally active ghrelin receptor agonist in development for non-small cell lung cancer (NSCLC)-related anorexia/cachexia

This dual mechanism highlights the critical role of SYNCRIP in modulating SIRT1 expression and function in GBM