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Left panel : Low-dose IV ACh primarily activates endothelial M3 muscarinic receptors, stimulating nitric oxide (NO) release and vascular smooth muscle relaxation, resulting in arterial vasodilation and reduced blood pressure

The two splice variants of the hybrid receptors were significantly more responsive to IGF1 than insulin with respective EC50 values for Hybrid-A and Hybrid-B hybrid receptors of 6 3 nM and 12 2 nM with IGF1 and 342 121 nM and 325 88 nM with insulin (Table 1)

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