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Amyloid load in nondemented brains correlates with APOE 4

Folate-mediated one-carbon metabolism fuels the methionine cycle, which supports multiple physiological processes, such as amino acid homeostasis, epigenetic maintenance and redox balance [28, 42]

Finerenone, a novel non-steroidal selective MR antagonist (MRA), demonstrates fewer adverse effects on serum potassium levels and renal function compared to steroidal MRAs which have been approved by FDA for treatment of DKD (208)

Intracellular adenosine is rapidly metabolized either via phosphorylation to adenosine monophosphate by adenosine kinase or via deamination to inosine by adenosine deaminase in the cytosol