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67,68 Specifically, female sex hormones including estradiol (e.g., 17-oestradiol) 69 protect female proopiomelanocortin (POMC) neurons from IR by enhancing POMC neuronal excitability and coupling insulin receptors to transient receptor potential (TRPC) channel activation

In summary, we put forward that targeting mature OLs is an untapped therapeutic avenue to support CNS health in the context of neurological disorders

Each peptide component is structurally optimized to maintain integrity under laboratory conditions while resisting rapid degradation

Abstract Parkinsons disease (PD) is increasingly recognized as a multisystem disorder in which pathogenic processes may originate in the gastrointestinal tract