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In TRIUMPH-4 reporting, dysesthesia occurred: More frequently at higher dose levels Much more commonly than placebo Importantly, it appears: Newly identified compared to earlier Phase 2 reporting Under ongoing evaluation within the Phase 3 programme Not clearly associated with high discontinuation rates in early reporting For UK researchers, this is an area worth monitoring, particularly as more Phase 3 trials complete and adverse event profiles become clearer across broader populations

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The Journal of Physiology, 591, 4655-4666

Danuglipron (from Pfizer) showed mixed results and faced development challenges