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Such mutations impair cellular uptake of riboflavin, leading to reduced FMN and FAD synthesis and consequent dysfunction of mitochondrial FAD-dependent enzymes, culminating in axonal degeneration, motor neuron disease, and sensory neuropathy

She points out that obesity, itself, is a severe and chronic disease that carries a high risk for heart disease, strokes, fatty liver disease that could lead to liver cancer, as well as diabetes that can result in kidney disease

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Patients should report cramps promptly, detailing their frequency, duration, and severity to help healthcare providers adjust treatment accordingly