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For cocaine use disorder, an ongoing clinical trial is registered (NCT07227948), and there is also an ongoing trial for methamphetamine use disorder (NCT07204249)

The MHRA has licensed several GLP-1 agonists for use in the UK, and NICE guidelines (NG28) recommend them for specific patient groups, particularly those with type 2 diabetes who have not achieved adequate control with other medications or who have additional cardiovascular risk factors

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Through dual pathway activation, tirzepatide improves glycemic control and induces substantial weight loss across clinical trials (15)