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Provides neuroprotective, gastroprotective, cardioprotective, and musculoskeletal protective effects via VEGFR2 and ERK1/2 signaling

Currently, there are a total of ten FDA-approved indications for hGH therapy [5]: Growth hormone deficiency in children and adults (GHD) Growth failure due to chronic renal insufficiency Muscle wasting due to AIDS Noonan syndrome Prader-Willi syndrome Short bowel syndrome (SBS) Short stature homeobox (SHOX)-containing gene deficiency Small-for-gestational-age infants Turner syndrome Recombinant hGH therapy can effectively and dose-dependently increase serum GH levels, hence its use in managing the symptoms of GHD in children and adults

A gradual transition, supported by dietary and activity adjustments, helps preserve results

Acknowledgements This work was funded by the DFG grant DE 1431/20-1 to M.D