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Finally, animal-to-human translational limitations are significant: germ-free mouse models and CUMS paradigms involve physiological conditions that do not faithfully recapitulate human psychiatric or functional gastrointestinal disorders, and microbiota transplant experiments in rodents cannot be directly extrapolated to clinical practice

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In general, tirzepatide tends to produce: Greater total weight loss over time, particularly in patients with metabolic dysfunction Stronger appetite suppression , including reduced cravings and food noise Faster metabolic response due to dual hormone pathway activation Because tirzepatide influences both appetite regulation and insulin sensitivity, it is often more effective for patients with insulin resistance, blood sugar instability, or stubborn weight that has not responded to diet, exercise, or GLP-1 therapy alone

Postoperative opioid consumption among cannabis users did not differ significantly from nonusers