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These benefits appear to reflect both improvements in traditional risk factors - weight, blood pressure, lipid profiles, glycemic control - and potentially direct cardioprotective effects mediated by GLP-1 receptors expressed in cardiomyocytes and vascular endothelium

New or worsening heat intolerance in an adult always warrants evaluation particularly when accompanied by weight loss, heart palpitations, tremor, or sweating disproportionate to ambient temperature

Unlike opioid-based treatments, they do not carry risks of dependency