[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Okumura K, Itoh A, Isogai E, Hirose K, Hosokawa Y, Abiko Y, et al
Persistent gastrointestinal issues such as severe vomiting, abdominal pain, ongoing constipation, or difficulty passing gas also need to be addressed
doi: 10.1053/j.gastro.2009.12.054 Summary Keywords immunometabolism, Th17/Treg balance, autoimmune diseases, therapeutic target, mTOR Citation Hu Y, Zhao Q, Dai H, Wu Y, Tang X, Zhang N, Jiang H, Rui H and Liu B (2025) Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review
NAC at doses exceeding 1,800mg daily can theoretically deplete copper and zinc over months of continuous use, but standard dosing (6001,200mg daily) poses no nutritional depletion risk when combined with adequate dietary intake