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Bipolar disorder Bipolar disorder (BD) is a common psychiatric disorder, characterised by alternating depressive and manic moods, and can be a significant cause of disability and morbidity

XO activity is significantly increased in patients with depression, and xanthine and XO produce superoxide anions and free radicals that generate oxidative stress, leading to cellular damage and death

Mohammed YH, Yamada M, Lin LL, Grice JE, Roberts MS, Raphael AP, et al

NO influences protein kinase B (Akt) signaling though a cGMP/phosphoinositide 3-kinase (PI3K) dependent pathway, which is the primary pathway for upregulating translation initiation required for muscle protein synthesis