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The evolving treatment landscape includes a diverse array of therapeutic options, such as H3 histamine receptor inverse agonists/antagonists (WAKIX [pitolisant]), therapies targeting extra-oral bitter taste receptors (TAS2R) (ARD-101), PDE-10 inhibitors (PBF-999), triple monoamine reuptake inhibitors (CSTI-500), melanocortin-4 receptor agonists (Setmelanotide), among others