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But I have come across similar reports describing something similar to a 48 hour half-life

A specific protease site engineered between the GST moiety and the protein of interest allows removal of the GST moiety from the target recombinant protein

According to a recent study (144), the lncRNA HEPFAL acts on SLC7A11 and reduces its expression, resulting in a decrease in the amount of cystine transported into the cell and, as a result, a decrease in the intracellular GSH level, which effectively inhibits the iron apoptosis function of GPX4 and, ultimately, iron apoptosis in tumor cells

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