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To determine if the observed effects of liraglutide to increase bihormonal insulin + glucagon + cells are mediated by the cell GLP-1R, we assessed the effect of liraglutide treatment on insulin and glucagon coexpression in our cell GLP-1RKO mouse line

- Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1, NEJM 2022, n=2,539) Wilding JPH et al

For a comparison of individual clinical trial results: Tirzepatide (Zepbound) : Up to 22.5% average weight loss Semaglutide (Wegovy injectable) : Up to 14.9% average weight loss Semaglutide (Wegovy Pill): Up to 16.6% average weight loss Liraglutide (Saxenda) : ~8% average weight loss Phentermine-topiramate (Qsymia) : 711% weight loss depending on dose Naltrexone-bupropion (Contrave) : ~59% average weight loss These commonly used medications for obesity decrease appetite, improve satiety, and support metabolic health

doi: 10.1016/j.jad.2024.10.062 22 McLaughlinA